Drug interactions
Aspirin + Hydrochlorothiazide-valsartan
Severity: Moderate
Aspirin and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-inflammatory doses of aspirin can blunt the antihypertensive effect of valsartan and hydrochlorothiazide by reducing renal prostaglandin synthesis and promoting sodium and fluid retention. In volume-depleted or elderly patients the combination of an ARB, a diuretic and an NSAID-type drug can worsen renal function. Low-dose aspirin has much less effect.
What this interaction means in plain words
Aspirin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing the antihypertensive effect and impairing glomerular filtration under ARB and diuretic therapy.
What to do
Monitor blood pressure, serum creatinine and potassium when aspirin at analgesic or anti-inflammatory doses is used; ensure adequate hydration. Low-dose aspirin for cardiovascular prevention generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Aspirin with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Aspirin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-inflammatory doses of aspirin can blunt the antihypertensive effect of valsartan and hydrochlorothiazide by reducing renal prostaglandin synthesis and promoting sodium and fluid retention. In volume-depleted or elderly patients the combination of an ARB, a diuretic and an NSAID-type drug can worsen renal function. Low-dose aspirin has much less effect.
How serious is the interaction between Aspirin and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when aspirin at analgesic or anti-inflammatory doses is used; ensure adequate hydration. Low-dose aspirin for cardiovascular prevention generally needs no change.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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