Drug interactions
Aspirin + Insulin glargine-lixisenatide
Severity: Moderate
Aspirin and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose salicylates can enhance the glucose-lowering effect of insulin and increase the risk of hypoglycemia. Low-dose aspirin for cardioprotection is unlikely to matter.
What this interaction means in plain words
Aspirin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates at high doses increase insulin secretion and peripheral glucose utilization, adding to insulin's effect.
What to do
With analgesic or anti-inflammatory doses of aspirin, monitor glucose more often and reduce the insulin dose if hypoglycemia occurs. No change is needed for low-dose aspirin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Aspirin with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Aspirin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose salicylates can enhance the glucose-lowering effect of insulin and increase the risk of hypoglycemia. Low-dose aspirin for cardioprotection is unlikely to matter.
How serious is the interaction between Aspirin and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With analgesic or anti-inflammatory doses of aspirin, monitor glucose more often and reduce the insulin dose if hypoglycemia occurs. No change is needed for low-dose aspirin.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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