Drug interactions
Dulaglutide + Insulin glargine-lixisenatide
Severity: Major
Dulaglutide and Insulin glargine-lixisenatide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide is a GLP-1 receptor agonist, so combining it with a product that already contains lixisenatide duplicates therapy. It gives no added benefit and increases gastrointestinal adverse effects and hypoglycemia risk.
What this interaction means in plain words
Dulaglutide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dulaglutide belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Therapeutic duplication of GLP-1 receptor agonism with additive glucose lowering.
What to do
Avoid using two GLP-1 receptor agonists together; use only one agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
- Glipizide + Insulin glargine-lixisenatide Major
Other interactions of Dulaglutide
- Dulaglutide + Insulin degludec-liraglutide Major
- Alogliptin-metformin + Dulaglutide Moderate
- Alogliptin-pioglitazone + Dulaglutide Moderate
- Alogliptin + Dulaglutide Moderate
- Chlorpropamide + Dulaglutide Moderate
- Dulaglutide + Empagliflozin-linagliptin Moderate
Frequently asked questions
Can I take Dulaglutide with Insulin glargine-lixisenatide?
MediHelp rates the interaction as major. Dulaglutide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dulaglutide is a GLP-1 receptor agonist, so combining it with a product that already contains lixisenatide duplicates therapy. It gives no added benefit and increases gastrointestinal adverse effects and hypoglycemia risk.
How serious is the interaction between Dulaglutide and Insulin glargine-lixisenatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two GLP-1 receptor agonists together; use only one agent.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Ethanol. The full list is on the Insulin glargine-lixisenatide page.
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