Drug interactions
Acetylsalicylic acid + Irbesartan
Severity: Moderate
Acetylsalicylic acid and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic or anti-inflammatory doses of aspirin can blunt the blood pressure lowering effect of irbesartan. In combination, they can also impair renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin is much less likely to cause a meaningful effect.
What this interaction means in plain words
Acetylsalicylic acid and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Irbesartan belongs to Cardiovascular.
Why it happens
Aspirin inhibits synthesis of vasodilatory renal prostaglandins, reducing renal perfusion and antagonising the antihypertensive effect, while the ARB reduces efferent arteriolar tone, so renal function is compromised.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing aspirin doses at anti-inflammatory levels. Ensure adequate hydration and prefer low-dose aspirin or an alternative analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Acetylsalicylic acid with Irbesartan?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic or anti-inflammatory doses of aspirin can blunt the blood pressure lowering effect of irbesartan. In combination, they can also impair renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin is much less likely to cause a meaningful effect.
How serious is the interaction between Acetylsalicylic acid and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing aspirin doses at anti-inflammatory levels. Ensure adequate hydration and prefer low-dose aspirin or an alternative analgesic where possible.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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