Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Irbesartan
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Irbesartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers (valsartan plus irbesartan) provides dual renin-angiotensin blockade without added benefit. It increases the risk of hypotension, hyperkalemia, and renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade produces additive hypotension, reduced aldosterone effect, and reduced glomerular filtration.
What to do
Avoid combining two ARBs and use a single agent. If this was done, discontinue one and check serum potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-olmesartan-hydrochlorothiazide + Irbesartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Irbesartan?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers (valsartan plus irbesartan) provides dual renin-angiotensin blockade without added benefit. It increases the risk of hypotension, hyperkalemia, and renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Irbesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs and use a single agent. If this was done, discontinue one and check serum potassium and creatinine.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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