Drug interactions
Irbesartan + Sparsentan
Severity: Contraindicated
Irbesartan and Sparsentan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding an ARB produces excessive blockade of the angiotensin pathway. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, including acute kidney injury.
What this interaction means in plain words
Irbesartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Irbesartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Why it happens
Additive pharmacodynamic angiotensin II type 1 receptor blockade, since sparsentan already has ARB activity.
What to do
Do not combine; stop the ARB before starting sparsentan. Sparsentan labeling contraindicates concomitant ARBs, ACE inhibitors and aliskiren.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Irbesartan
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Irbesartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Irbesartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding an ARB produces excessive blockade of the angiotensin pathway. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, including acute kidney injury.
How serious is the interaction between Irbesartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop the ARB before starting sparsentan. Sparsentan labeling contraindicates concomitant ARBs, ACE inhibitors and aliskiren.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Amifostine, Amiloride. The full list is on the Irbesartan page.
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