Drug interactions
Acetylsalicylic acid + Lesinurad
Severity: Moderate
Acetylsalicylic acid and Lesinurad: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
What this interaction means in plain words
Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Lesinurad belongs to Genitourinary.
Why it happens
Salicylates interfere with renal urate handling at the tubular level, and this may counteract the uricosuric effect, though the exact mechanism is not firmly established.
What to do
Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetylsalicylic acid and Lesinurad, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
- Ethinyl estradiol-drospirenone + Lesinurad Moderate
Frequently asked questions
Can I take Acetylsalicylic acid with Lesinurad?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
How serious is the interaction between Acetylsalicylic acid and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
