Drug reference
lesinurad
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Genitourinary (Anti Gout)
Mechanism of action
Selective uric acid reabsorption inhibitor (SURI); it acts by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. It also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia
Common side effects
- Headache
- Influenza
- Renal failure
- GERD
- Increased creatinine
Contraindications
- Severe renal impairment (estimated CrCl <30 mL/min), end-stage renal disease, kidney transplant recipients, or patients on dialysis Tumor lysis syndrome or Lesch-Nyhan syndrome
Related conditions
Frequently asked questions
What drug class is lesinurad?
lesinurad belongs to: Genitourinary.
How does lesinurad work?
Selective uric acid reabsorption inhibitor (SURI); it acts by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. It also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia
What are the common side effects of lesinurad?
Headache, Influenza, Renal failure, GERD, Increased creatinine
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