Drug interactions
Apalutamide + Lesinurad
Severity: Moderate
Apalutamide and Lesinurad: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP3A4 and CYP2C9, and lesinurad is mainly cleared by CYP2C9. Lesinurad exposure may fall, reducing its serum urate-lowering efficacy.
What this interaction means in plain words
Apalutamide and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Lesinurad belongs to Genitourinary.
Why it happens
Apalutamide induces CYP2C9, increasing the metabolism of lesinurad.
What to do
Monitor serum uric acid and assess for loss of efficacy. Consider an alternative urate-lowering therapy if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Lesinurad?
MediHelp rates the interaction as moderate. Apalutamide and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP3A4 and CYP2C9, and lesinurad is mainly cleared by CYP2C9. Lesinurad exposure may fall, reducing its serum urate-lowering efficacy.
How serious is the interaction between Apalutamide and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and assess for loss of efficacy. Consider an alternative urate-lowering therapy if the response is inadequate.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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