Drug interactions
Acetylsalicylic acid + Mifepristone
Severity: Moderate
Acetylsalicylic acid and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin's antiplatelet effect could add to the bleeding that occurs after mifepristone-induced abortion. Heavy blood loss is the concern.
What this interaction means in plain words
Acetylsalicylic acid and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Mifepristone belongs to Endocrine.
Why it happens
Additive bleeding tendency
What to do
Where possible avoid regular aspirin/NSAIDs around the mifepristone regimen and counsel on bleeding warning signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Mifepristone?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin's antiplatelet effect could add to the bleeding that occurs after mifepristone-induced abortion. Heavy blood loss is the concern.
How serious is the interaction between Acetylsalicylic acid and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible avoid regular aspirin/NSAIDs around the mifepristone regimen and counsel on bleeding warning signs.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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