Drug reference
mifepristone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (SERMs)
Mechanism of action
Stimulate uterine contractility: antiprogestin; also increases prostaglandins by inhibiting prostaglandin dehydrogenase Blocks cortisol receptor binding, and thereby reduces excess cortisol effects (eg, hyperglycemia) associated with endogenous Cushing syndrome
Common side effects
- Dizziness
- Vomiting
- Headache
- Nausea
- Abdominal pain, cramping
- Uterine cramping
- Diarrhea
Known interactions (23)
- apixaban + mifepristone Contraindicated
- argatroban + mifepristone Contraindicated
- cisapride + mifepristone Contraindicated
- cyclosporin + mifepristone Contraindicated
- dabigatran etexilate + mifepristone Contraindicated
- dalteparin + mifepristone Contraindicated
- deflazacort + mifepristone Contraindicated
- dexamethasone + mifepristone Contraindicated
- enoxaparin + mifepristone Contraindicated
- ergotamine + mifepristone Contraindicated
- fludrocortisone + mifepristone Contraindicated
- hydrocortisone + mifepristone Contraindicated
- alfuzosin + mifepristone Major
- budesonide + mifepristone Major
- colchicine + mifepristone Major
- dronedarone + mifepristone Major
- eletriptan + mifepristone Major
- eplerenone + mifepristone Major
- fondaparinux + mifepristone Major
- heparin + mifepristone Major
- acetylsalicylic acid + mifepristone Moderate
- ethinyl estradiol-levonorgestrel + mifepristone Moderate
- goserelin + mifepristone Moderate
Related conditions
Frequently asked questions
What drug class is mifepristone?
mifepristone belongs to: Endocrine.
How does mifepristone work?
Stimulate uterine contractility: antiprogestin; also increases prostaglandins by inhibiting prostaglandin dehydrogenase Blocks cortisol receptor binding, and thereby reduces excess cortisol effects (eg, hyperglycemia) associated with endogenous Cushing syndrome
What are the common side effects of mifepristone?
Dizziness, Vomiting, Headache, Nausea, Abdominal pain, cramping, Uterine cramping, Diarrhea
Which drugs interact with mifepristone?
apixaban, argatroban, cisapride, cyclosporin, dabigatran etexilate, dalteparin, deflazacort, dexamethasone, enoxaparin, ergotamine, fludrocortisone, hydrocortisone, alfuzosin, budesonide, colchicine
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