Drug interactions
Cortisone + Mifepristone
Severity: Contraindicated
Cortisone and Mifepristone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone blocks glucocorticoid receptors, so it may reduce the effect of cortisone and precipitate adrenal insufficiency in patients who depend on long-term corticosteroids. Labeling contraindicates mifepristone for abortion in patients on long-term corticosteroid therapy.
What this interaction means in plain words
Cortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Mifepristone antagonizes glucocorticoid receptors, opposing the effect of cortisone.
What to do
Do not use mifepristone in patients on long-term corticosteroid replacement or treatment. Choose another abortion method or manage under specialist supervision.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Dalteparin + Mifepristone Contraindicated
Frequently asked questions
Can I take Cortisone with Mifepristone?
MediHelp rates the interaction as contraindicated. Cortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone blocks glucocorticoid receptors, so it may reduce the effect of cortisone and precipitate adrenal insufficiency in patients who depend on long-term corticosteroids. Labeling contraindicates mifepristone for abortion in patients on long-term corticosteroid therapy.
How serious is the interaction between Cortisone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid replacement or treatment. Choose another abortion method or manage under specialist supervision.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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