Drug interactions
Acetylsalicylic acid + Milnacipran
Severity: Moderate
Acetylsalicylic acid and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Milnacipran, like other serotonin-norepinephrine reuptake inhibitors, impairs platelet function and increases bleeding risk, especially upper gastrointestinal bleeding, when combined with aspirin.
What this interaction means in plain words
Acetylsalicylic acid and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
Inhibition of platelet serotonin uptake reduces platelet aggregation, adding to aspirin's antiplatelet and mucosal-damaging effects.
What to do
Monitor for signs of bleeding such as melena or bruising, and consider gastroprotection with a proton pump inhibitor in patients at higher GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetylsalicylic acid and Milnacipran, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Milnacipran?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Milnacipran, like other serotonin-norepinephrine reuptake inhibitors, impairs platelet function and increases bleeding risk, especially upper gastrointestinal bleeding, when combined with aspirin.
How serious is the interaction between Acetylsalicylic acid and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding such as melena or bruising, and consider gastroprotection with a proton pump inhibitor in patients at higher GI risk.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
