Drug interactions
Milnacipran + Rasagiline
Severity: Contraindicated
Milnacipran and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline, an MAO-B inhibitor, combined with milnacipran carries a risk of serotonin syndrome. Milnacipran labeling contraindicates use with MAO inhibitors.
What this interaction means in plain words
Milnacipran and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Milnacipran belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition plus serotonin-noradrenaline reuptake inhibition increases monoamine levels.
What to do
Do not coadminister. Wait at least 14 days after stopping rasagiline before starting milnacipran, and at least 5 days after stopping milnacipran before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Safinamide Contraindicated
- Milnacipran + Selegiline Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Milnacipran with Rasagiline?
MediHelp rates the interaction as contraindicated. Milnacipran and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline, an MAO-B inhibitor, combined with milnacipran carries a risk of serotonin syndrome. Milnacipran labeling contraindicates use with MAO inhibitors.
How serious is the interaction between Milnacipran and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Wait at least 14 days after stopping rasagiline before starting milnacipran, and at least 5 days after stopping milnacipran before starting rasagiline.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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