Drug interactions
Milnacipran + Procarbazine
Severity: Contraindicated
Milnacipran and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting activity, so combining it with milnacipran may precipitate serotonin syndrome or hypertensive reactions. The risk is inferred mostly from MAOI class effects.
What this interaction means in plain words
Milnacipran and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Milnacipran belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine adds to milnacipran's serotonin and noradrenaline reuptake inhibition.
What to do
Avoid the combination and keep at least 14 days between stopping procarbazine and starting milnacipran. Consider a non-serotonergic option for symptom control.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
- Milnacipran + Selegiline Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Milnacipran with Procarbazine?
MediHelp rates the interaction as contraindicated. Milnacipran and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, so combining it with milnacipran may precipitate serotonin syndrome or hypertensive reactions. The risk is inferred mostly from MAOI class effects.
How serious is the interaction between Milnacipran and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and keep at least 14 days between stopping procarbazine and starting milnacipran. Consider a non-serotonergic option for symptom control.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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