Drug interactions
Acetylsalicylic acid + Piperacillin
Severity: Moderate
Acetylsalicylic acid and Piperacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piperacillin can impair platelet function at high doses, which may add to aspirin's antiplatelet effect and raise bleeding risk. Protein binding displacement by salicylate is of little practical importance.
What this interaction means in plain words
Acetylsalicylic acid and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Piperacillin belongs to Anti Bacterial.
Why it happens
Additive platelet dysfunction from penicillin-induced platelet membrane effects and aspirin's cyclooxygenase inhibition.
What to do
Monitor for bruising and bleeding and check coagulation parameters and platelet counts in patients on high-dose piperacillin. Be especially careful with renal impairment or concurrent anticoagulants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
- Avelumab + Piperacillin Moderate
Frequently asked questions
Can I take Acetylsalicylic acid with Piperacillin?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet function at high doses, which may add to aspirin's antiplatelet effect and raise bleeding risk. Protein binding displacement by salicylate is of little practical importance.
How serious is the interaction between Acetylsalicylic acid and Piperacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and bleeding and check coagulation parameters and platelet counts in patients on high-dose piperacillin. Be especially careful with renal impairment or concurrent anticoagulants.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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