Drug interactions
Acetylsalicylic acid + Probenecid
Severity: Moderate
Acetylsalicylic acid and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin, particularly at analgesic doses, antagonizes the uricosuric action of probenecid and can reduce its ability to lower serum urate. Low-dose aspirin has a smaller effect.
What this interaction means in plain words
Acetylsalicylic acid and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Salicylate competes with probenecid for renal tubular organic anion transport and blocks urate excretion, counteracting its uricosuric effect.
What to do
Avoid analgesic doses of aspirin in patients taking probenecid for gout and use paracetamol or another suitable analgesic. Monitor serum uric acid if low-dose aspirin is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Acetylsalicylic acid with Probenecid?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin, particularly at analgesic doses, antagonizes the uricosuric action of probenecid and can reduce its ability to lower serum urate. Low-dose aspirin has a smaller effect.
How serious is the interaction between Acetylsalicylic acid and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid analgesic doses of aspirin in patients taking probenecid for gout and use paracetamol or another suitable analgesic. Monitor serum uric acid if low-dose aspirin is required.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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