Drug interactions
Baricitinib + Probenecid
Severity: Major
Baricitinib and Probenecid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits renal organic anion transporter 3, which helps clear baricitinib into urine. Baricitinib exposure rises, which may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
What this interaction means in plain words
Baricitinib and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of baricitinib reduces its elimination.
What to do
Baricitinib labeling advises against using it with strong OAT3 inhibitors such as probenecid; if unavoidable, reduce the baricitinib dose as per labeling. Monitor for infection and hematologic abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
- Probenecid + Roxadustat Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Probenecid?
MediHelp rates the interaction as major. Baricitinib and Probenecid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid inhibits renal organic anion transporter 3, which helps clear baricitinib into urine. Baricitinib exposure rises, which may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
How serious is the interaction between Baricitinib and Probenecid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Baricitinib labeling advises against using it with strong OAT3 inhibitors such as probenecid; if unavoidable, reduce the baricitinib dose as per labeling. Monitor for infection and hematologic abnormalities.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Ceftazidime / avibactam. The full list is on the Probenecid page.
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