Drug interactions
Acetylsalicylic acid + Sulindac
Severity: Major
Acetylsalicylic acid and Sulindac: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining aspirin with sulindac increases the risk of GI ulceration and bleeding. Renal effects may also be additive, and aspirin levels or effect may be altered.
What this interaction means in plain words
Acetylsalicylic acid and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Sulindac belongs to Musculoskeletal.
Why it happens
Both inhibit COX-mediated gastroprotective prostaglandins and platelet function, producing additive mucosal injury and bleeding tendency.
What to do
Avoid concurrent use where possible; if aspirin is required for cardioprotection, consider an alternative analgesic or add a PPI. Monitor for GI bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
- Amlodipine-hydrochlorothiazide-valsartan + Sulindac Major
Frequently asked questions
Can I take Acetylsalicylic acid with Sulindac?
MediHelp rates the interaction as major. Acetylsalicylic acid and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining aspirin with sulindac increases the risk of GI ulceration and bleeding. Renal effects may also be additive, and aspirin levels or effect may be altered.
How serious is the interaction between Acetylsalicylic acid and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if aspirin is required for cardioprotection, consider an alternative analgesic or add a PPI. Monitor for GI bleeding and renal function.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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