Drug reference
sulindac
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2). May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. These effects may contribute to its anti-inflammatory activity
Common side effects
- GI pain
- Dyspepsia
- Constipation
- Dizziness
- Headache
- Nausea
- Diarrhea
Contraindications
- Hypersensitivity to drug or excipients In the setting of CABG surgery History of asthma, urticaria, or any other type of reaction after taking aspirin or other NSAIDs
Known interactions (1)
- Celecoxib + sulindac Major
Related conditions
Frequently asked questions
What drug class is sulindac?
sulindac belongs to: Musculoskeletal.
How does sulindac work?
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2). May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. These effects may contribute to its anti-inflammatory activity
What are the common side effects of sulindac?
GI pain, Dyspepsia, Constipation, Dizziness, Headache, Nausea, Diarrhea
Which drugs interact with sulindac?
Celecoxib
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