Drug interactions
Ketorolac intranasal + Sulindac
Severity: Contraindicated
Ketorolac intranasal and Sulindac: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac and intranasal ketorolac together duplicate NSAID effects, raising the risk of gastrointestinal hemorrhage, kidney injury and cardiovascular events. Systemic absorption of intranasal ketorolac means the oral ketorolac restriction applies.
What this interaction means in plain words
Ketorolac intranasal and Sulindac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Do not use together; keep to one NSAID. Use a non-NSAID analgesic if more pain control is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sulindac
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
- Amlodipine-hydrochlorothiazide-valsartan + Sulindac Major
Frequently asked questions
Can I take Ketorolac intranasal with Sulindac?
MediHelp rates the interaction as contraindicated. Ketorolac intranasal and Sulindac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sulindac and intranasal ketorolac together duplicate NSAID effects, raising the risk of gastrointestinal hemorrhage, kidney injury and cardiovascular events. Systemic absorption of intranasal ketorolac means the oral ketorolac restriction applies.
How serious is the interaction between Ketorolac intranasal and Sulindac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; keep to one NSAID. Use a non-NSAID analgesic if more pain control is needed.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac, Aceclofenac, Acetylsalicylic acid. The full list is on the Sulindac page.
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