Drug interactions
Acetylsalicylic acid + Tiludronate
Severity: Moderate
Acetylsalicylic acid and Tiludronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin taken with oral tiludronate may reduce its bioavailability, and tiludronate absorption is also reduced by food and divalent cations. Aspirin can also add to upper gastrointestinal irritation from bisphosphonates.
What this interaction means in plain words
Acetylsalicylic acid and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Tiludronate belongs to Musculoskeletal.
Why it happens
Reduced oral absorption of tiludronate when taken with aspirin, plus additive gastric mucosal irritation.
What to do
Give tiludronate with water at least two hours before or after aspirin. Monitor for upper gastrointestinal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetylsalicylic acid and Tiludronate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Tiludronate
- Aluminum hydroxide + Tiludronate Moderate
- Calcium acetate + Tiludronate Moderate
- Calcium carbonate + Tiludronate Moderate
- Calcium chloride + Tiludronate Moderate
- Calcium citrate + Tiludronate Moderate
- Calcium gluconate + Tiludronate Moderate
Frequently asked questions
Can I take Acetylsalicylic acid with Tiludronate?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin taken with oral tiludronate may reduce its bioavailability, and tiludronate absorption is also reduced by food and divalent cations. Aspirin can also add to upper gastrointestinal irritation from bisphosphonates.
How serious is the interaction between Acetylsalicylic acid and Tiludronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give tiludronate with water at least two hours before or after aspirin. Monitor for upper gastrointestinal symptoms.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
