Drug interactions
Calcium citrate + Tiludronate
Severity: Moderate
Calcium citrate and Tiludronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium citrate supplements can chelate tiludronate in the gut and reduce its absorption. Efficacy of the bisphosphonate may be diminished.
What this interaction means in plain words
Calcium citrate and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Divalent calcium cations chelate tiludronate in the gastrointestinal tract, forming poorly absorbable complexes.
What to do
Give calcium citrate at least 2 hours away from tiludronate, which should be taken fasting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiludronate
- Acetylsalicylic acid + Tiludronate Moderate
- Aluminum hydroxide + Tiludronate Moderate
- Calcium acetate + Tiludronate Moderate
- Calcium carbonate + Tiludronate Moderate
- Calcium chloride + Tiludronate Moderate
- Calcium gluconate + Tiludronate Moderate
Frequently asked questions
Can I take Calcium citrate with Tiludronate?
MediHelp rates the interaction as moderate. Calcium citrate and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium citrate supplements can chelate tiludronate in the gut and reduce its absorption. Efficacy of the bisphosphonate may be diminished.
How serious is the interaction between Calcium citrate and Tiludronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give calcium citrate at least 2 hours away from tiludronate, which should be taken fasting.
What other medicines interact with Tiludronate?
MediHelp also lists interactions of Tiludronate with, for example, Acetylsalicylic acid, Aluminum hydroxide, Calcium acetate. The full list is on the Tiludronate page.
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