Drug interactions
Calcium gluconate + Tiludronate
Severity: Moderate
Calcium gluconate and Tiludronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium gluconate can bind tiludronate in the gut and reduce absorption. This may lessen the drug's benefit on bone.
What this interaction means in plain words
Calcium gluconate and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Tiludronate belongs to Musculoskeletal.
Why it happens
Divalent calcium cations chelate tiludronate in the gastrointestinal tract, forming poorly absorbable complexes.
What to do
Separate oral calcium gluconate from tiludronate by at least 2 hours. Intravenous calcium is not affected by this mechanism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiludronate
- Acetylsalicylic acid + Tiludronate Moderate
- Aluminum hydroxide + Tiludronate Moderate
- Calcium acetate + Tiludronate Moderate
- Calcium carbonate + Tiludronate Moderate
- Calcium chloride + Tiludronate Moderate
- Calcium citrate + Tiludronate Moderate
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Tiludronate?
MediHelp rates the interaction as moderate. Calcium gluconate and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium gluconate can bind tiludronate in the gut and reduce absorption. This may lessen the drug's benefit on bone.
How serious is the interaction between Calcium gluconate and Tiludronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral calcium gluconate from tiludronate by at least 2 hours. Intravenous calcium is not affected by this mechanism.
What other medicines interact with Tiludronate?
MediHelp also lists interactions of Tiludronate with, for example, Acetylsalicylic acid, Aluminum hydroxide, Calcium acetate. The full list is on the Tiludronate page.
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