Drug interactions
Acetylsalicylic acid + Vancomycin
Severity: Minor
Acetylsalicylic acid and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates may add to ototoxicity and nephrotoxicity risk with vancomycin, and clearance could be reduced in neonates or patients with renal impairment. The evidence is limited.
What this interaction means in plain words
Acetylsalicylic acid and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
Possible reduced renal clearance and additive ototoxic or nephrotoxic effects.
What to do
Use standard vancomycin level and renal function monitoring. Take extra care in neonates and patients with renal impairment on high-dose aspirin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Acetylsalicylic acid with Vancomycin?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates may add to ototoxicity and nephrotoxicity risk with vancomycin, and clearance could be reduced in neonates or patients with renal impairment. The evidence is limited.
How serious is the interaction between Acetylsalicylic acid and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard vancomycin level and renal function monitoring. Take extra care in neonates and patients with renal impairment on high-dose aspirin.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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