Drug interactions
Cephaloridine + Vancomycin
Severity: Major
Cephaloridine and Vancomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephaloridine is a markedly nephrotoxic cephalosporin, and combining it with vancomycin may increase the risk of kidney injury. Cephaloridine is obsolete and rarely available.
What this interaction means in plain words
Cephaloridine and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with cephaloridine causing proximal tubular injury.
What to do
Avoid the combination and choose a less nephrotoxic alternative; if used, monitor serum creatinine and urine output closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
- Colistin + Vancomycin Major
Frequently asked questions
Can I take Cephaloridine with Vancomycin?
MediHelp rates the interaction as major. Cephaloridine and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is a markedly nephrotoxic cephalosporin, and combining it with vancomycin may increase the risk of kidney injury. Cephaloridine is obsolete and rarely available.
How serious is the interaction between Cephaloridine and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a less nephrotoxic alternative; if used, monitor serum creatinine and urine output closely.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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