Drug interactions
Capreomycin + Vancomycin
Severity: Major
Capreomycin and Vancomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the kidneys and the inner ear, so combined use may increase the risk of nephrotoxicity and ototoxicity. Capreomycin is itself a significant nephrotoxin and ototoxin, so the combination deserves more than minor concern.
What this interaction means in plain words
Capreomycin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxic and ototoxic effects of both agents.
What to do
Avoid the combination where possible; if unavoidable, monitor serum creatinine, vancomycin trough levels and hearing regularly and adjust doses to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capreomycin and Vancomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
- Colistin + Vancomycin Major
Frequently asked questions
Can I take Capreomycin with Vancomycin?
MediHelp rates the interaction as major. Capreomycin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the kidneys and the inner ear, so combined use may increase the risk of nephrotoxicity and ototoxicity. Capreomycin is itself a significant nephrotoxin and ototoxin, so the combination deserves more than minor concern.
How serious is the interaction between Capreomycin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, monitor serum creatinine, vancomycin trough levels and hearing regularly and adjust doses to renal function.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Cephaloridine. The full list is on the Vancomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
