Drug interactions
Aspirin / citric acid / sodium bicarbonate + Cyclosporin
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin at analgesic doses inhibits renal prostaglandin synthesis, which can reduce renal blood flow and add to the nephrotoxicity of cyclosporine. Renal function may decline, particularly with dehydration or repeated dosing. The bicarbonate and citric acid components are not the main concern.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity: cyclosporine causes afferent arteriolar vasoconstriction, and aspirin removes the compensatory vasodilatory prostaglandins.
What to do
Avoid regular or high-dose aspirin; use paracetamol for analgesia where possible. If aspirin is needed, monitor serum creatinine and cyclosporine trough levels and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Cyclosporin?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin at analgesic doses inhibits renal prostaglandin synthesis, which can reduce renal blood flow and add to the nephrotoxicity of cyclosporine. Renal function may decline, particularly with dehydration or repeated dosing. The bicarbonate and citric acid components are not the main concern.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular or high-dose aspirin; use paracetamol for analgesia where possible. If aspirin is needed, monitor serum creatinine and cyclosporine trough levels and keep the patient well hydrated.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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