Drug interactions
Aspirin / citric acid / sodium bicarbonate + Deflazacort
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This effervescent aspirin product delivers a full analgesic aspirin dose, and with corticosteroids it raises the risk of gastric ulceration and bleeding. Buffering does not remove the systemic prostaglandin-mediated risk.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition and impaired mucosal healing.
What to do
Limit dose and duration, and consider a proton pump inhibitor in patients at risk. Monitor for dyspepsia, melena or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Deflazacort?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This effervescent aspirin product delivers a full analgesic aspirin dose, and with corticosteroids it raises the risk of gastric ulceration and bleeding. Buffering does not remove the systemic prostaglandin-mediated risk.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit dose and duration, and consider a proton pump inhibitor in patients at risk. Monitor for dyspepsia, melena or hematemesis.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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