Drug interactions
Aspirin / citric acid / sodium bicarbonate + Eprosartan-hydrochlorothiazide
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The analgesic doses of aspirin in this effervescent product can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide and increase the risk of kidney injury, particularly in older or dehydrated patients. The sodium bicarbonate content adds a sodium load that may also oppose blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, reducing renal perfusion and causing sodium and fluid retention, while sodium bicarbonate adds sodium load.
What to do
Limit use to short courses at the lowest effective dose and ensure adequate hydration. Monitor blood pressure, creatinine and potassium with repeated use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin / citric acid / sodium bicarbonate and Eprosartan-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The analgesic doses of aspirin in this effervescent product can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide and increase the risk of kidney injury, particularly in older or dehydrated patients. The sodium bicarbonate content adds a sodium load that may also oppose blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses at the lowest effective dose and ensure adequate hydration. Monitor blood pressure, creatinine and potassium with repeated use.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
