Drug interactions
Aspirin / citric acid / sodium bicarbonate + Fosinopril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic doses of aspirin can blunt the antihypertensive effect of ACE inhibitors and, in volume-depleted or elderly patients, worsen renal function. The sodium bicarbonate also adds a sodium load. Low-dose aspirin is much less of a concern.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis by aspirin reduces ACE inhibitor efficacy and renal perfusion.
What to do
Avoid regular use of analgesic-dose aspirin products in patients on fosinopril; if needed, ensure hydration and monitor blood pressure and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Fosinopril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic doses of aspirin can blunt the antihypertensive effect of ACE inhibitors and, in volume-depleted or elderly patients, worsen renal function. The sodium bicarbonate also adds a sodium load. Low-dose aspirin is much less of a concern.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of analgesic-dose aspirin products in patients on fosinopril; if needed, ensure hydration and monitor blood pressure and renal function.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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