Drug interactions
Aspirin / citric acid / sodium bicarbonate + Hydrochlorothiazide-telmisartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The effervescent product delivers analgesic-dose aspirin and a sodium load. This can blunt blood pressure control and raise the risk of kidney injury with telmisartan and hydrochlorothiazide, especially in volume-depleted or older patients.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal perfusion and sodium excretion, and the sodium load further opposes antihypertensive therapy.
What to do
Limit use to short courses, ensure hydration and monitor blood pressure, creatinine and potassium. Consider paracetamol as an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The effervescent product delivers analgesic-dose aspirin and a sodium load. This can blunt blood pressure control and raise the risk of kidney injury with telmisartan and hydrochlorothiazide, especially in volume-depleted or older patients.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses, ensure hydration and monitor blood pressure, creatinine and potassium. Consider paracetamol as an alternative analgesic.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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