Drug interactions
Aspirin / citric acid / sodium bicarbonate + Lisinopril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or higher doses, aspirin can blunt the antihypertensive effect of ACE inhibitors and, with volume depletion, impair renal function. The effect is much less with low-dose aspirin. The sodium bicarbonate also adds a sodium load.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces ACE inhibitor efficacy and renal perfusion.
What to do
Avoid regular high-dose use of this product in patients on lisinopril, particularly if elderly or volume depleted. Monitor blood pressure and renal function if use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Lisinopril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or higher doses, aspirin can blunt the antihypertensive effect of ACE inhibitors and, with volume depletion, impair renal function. The effect is much less with low-dose aspirin. The sodium bicarbonate also adds a sodium load.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular high-dose use of this product in patients on lisinopril, particularly if elderly or volume depleted. Monitor blood pressure and renal function if use is needed.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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