Drug interactions
Aspirin / citric acid / sodium bicarbonate + Measles mumps and rubella vaccine
Severity: Major
Aspirin / citric acid / sodium bicarbonate and Measles mumps and rubella vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Effervescent aspirin preparations deliver systemic salicylate, so the Reye syndrome concern after varicella-containing live vaccines applies. Labeling advises avoiding salicylates for six weeks after vaccination.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Salicylate exposure during vaccine-strain varicella infection is associated with Reye syndrome; mechanism not fully established.
What to do
Avoid aspirin-containing products for 6 weeks after varicella-containing vaccine; use paracetamol instead.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Measles mumps and rubella vaccine?
MediHelp rates the interaction as major. Aspirin / citric acid / sodium bicarbonate and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Effervescent aspirin preparations deliver systemic salicylate, so the Reye syndrome concern after varicella-containing live vaccines applies. Labeling advises avoiding salicylates for six weeks after vaccination.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Measles mumps and rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid aspirin-containing products for 6 weeks after varicella-containing vaccine; use paracetamol instead.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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