Drug interactions
Aspirin / citric acid / sodium bicarbonate + Mesalamine
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine can rarely cause interstitial nephritis and the aspirin in this effervescent analgesic can reduce renal prostaglandin-dependent perfusion. Together they may increase the risk of kidney injury.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity through salicylate-related renal effects and mesalamine-related interstitial nephritis.
What to do
Monitor serum creatinine periodically, especially with frequent aspirin use or renal impairment; prefer paracetamol for analgesia if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Mesalamine?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine can rarely cause interstitial nephritis and the aspirin in this effervescent analgesic can reduce renal prostaglandin-dependent perfusion. Together they may increase the risk of kidney injury.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine periodically, especially with frequent aspirin use or renal impairment; prefer paracetamol for analgesia if possible.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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