Drug interactions
Aspirin / citric acid / sodium bicarbonate + Moexipril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic or higher doses of aspirin can blunt the antihypertensive effect of ACE inhibitors and, in volume-depleted or elderly patients, may worsen renal function. The sodium bicarbonate content adds a sodium load that may also oppose blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis by aspirin reduces ACE inhibitor efficacy and renal perfusion.
What to do
Monitor blood pressure and serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol for pain relief where suitable, and avoid regular use of this effervescent product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Moexipril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic or higher doses of aspirin can blunt the antihypertensive effect of ACE inhibitors and, in volume-depleted or elderly patients, may worsen renal function. The sodium bicarbonate content adds a sodium load that may also oppose blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol for pain relief where suitable, and avoid regular use of this effervescent product.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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