Drug interactions
Aspirin / citric acid / sodium bicarbonate + Nilotinib
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The buffering agents raise gastric pH and may decrease nilotinib absorption. Aspirin also adds bleeding risk in a patient who may be thrombocytopenic.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH reduces nilotinib dissolution and absorption.
What to do
Separate the antacid from nilotinib by at least 2 hours before or after, and monitor platelet counts if aspirin is used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Nilotinib?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The buffering agents raise gastric pH and may decrease nilotinib absorption. Aspirin also adds bleeding risk in a patient who may be thrombocytopenic.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid from nilotinib by at least 2 hours before or after, and monitor platelet counts if aspirin is used regularly.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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