Drug interactions
Aspirin / citric acid / sodium bicarbonate + Propranolol
Severity: Minor
Aspirin / citric acid / sodium bicarbonate and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular use of analgesic-dose aspirin in effervescent products may weaken propranolol's antihypertensive effect. Sodium load from the bicarbonate may add to fluid retention.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aspirin inhibits prostaglandin synthesis, reducing renal sodium excretion and opposing beta-blocker effects.
What to do
Monitor blood pressure if used regularly and limit repeated use of the effervescent product in hypertensive patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Propranolol?
MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regular use of analgesic-dose aspirin in effervescent products may weaken propranolol's antihypertensive effect. Sodium load from the bicarbonate may add to fluid retention.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if used regularly and limit repeated use of the effervescent product in hypertensive patients.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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