Drug interactions
Aspirin / citric acid / sodium bicarbonate + Sacubitril-valsartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The analgesic doses in effervescent aspirin products can blunt valsartan's effect and worsen renal function in volume-depleted or elderly patients. The sodium load may also contribute to fluid retention in heart failure.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal perfusion and antagonizes angiotensin receptor blocker effects, with an added sodium load.
What to do
Avoid regular use and choose another analgesic where possible. If used, monitor renal function, potassium, blood pressure and fluid status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The analgesic doses in effervescent aspirin products can blunt valsartan's effect and worsen renal function in volume-depleted or elderly patients. The sodium load may also contribute to fluid retention in heart failure.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use and choose another analgesic where possible. If used, monitor renal function, potassium, blood pressure and fluid status.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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