Drug reference
sacubitril-valsartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Sacubitril: Neprilysin inhibitor; neprilysin is responsible for degradation of atrial and brain natriuretic peptide; the CVS and renal effects of sacubitril’s active metabolite in heart failure are attributed to the increased levels of peptides that are degraded by neprilysin; Valsartan: Angiotensin II receptor type I inhibitor.
Common side effects
- Dizziness
- Hyperkalemia
- Hypotension
- Cough
- Orthostasis
Boxed warnings
- Fetal toxicity Discontinue immediately when pregnancy is detected Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus
Contraindications
- Hypersensitivity to any component History of angioedema related to previous ACE inhibitor or ARB therapy Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitri…
Known interactions (4)
- benazepril + sacubitril-valsartan Contraindicated
- captopril + sacubitril-valsartan Contraindicated
- enalapril + sacubitril-valsartan Contraindicated
- fosinopril + sacubitril-valsartan Contraindicated
Related conditions
Frequently asked questions
What drug class is sacubitril-valsartan?
sacubitril-valsartan belongs to: Cardiovascular.
How does sacubitril-valsartan work?
Sacubitril: Neprilysin inhibitor; neprilysin is responsible for degradation of atrial and brain natriuretic peptide; the CVS and renal effects of sacubitril’s active metabolite in heart failure are attributed to the increased levels of peptides that are degraded by neprilysin; Valsartan: Angiotensin II receptor type I inhibitor.
What are the common side effects of sacubitril-valsartan?
Dizziness, Hyperkalemia, Hypotension, Cough, Orthostasis
Which drugs interact with sacubitril-valsartan?
benazepril, captopril, enalapril, fosinopril
Full monographs, dosing and an interaction checker in the MediHelp app
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