Drug interactions
Aspirin / citric acid / sodium bicarbonate + Trandolapril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic doses of aspirin can blunt the antihypertensive effect of ACE inhibitors and impair renal function in susceptible patients. Low-dose aspirin has little effect. The sodium load from the effervescent formulation may also oppose blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis by aspirin opposes ACE inhibitor-mediated vasodilation and renal effects.
What to do
Avoid regular analgesic-dose use if possible; monitor blood pressure and renal function. Low-dose aspirin for cardiovascular protection usually does not need to be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Trandolapril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic doses of aspirin can blunt the antihypertensive effect of ACE inhibitors and impair renal function in susceptible patients. Low-dose aspirin has little effect. The sodium load from the effervescent formulation may also oppose blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular analgesic-dose use if possible; monitor blood pressure and renal function. Low-dose aspirin for cardiovascular protection usually does not need to be stopped.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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