Drug interactions
Sacubitril-valsartan + Trandolapril
Severity: Contraindicated
Sacubitril-valsartan and Trandolapril: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining neprilysin inhibition with an ACE inhibitor greatly increases bradykinin-mediated angioedema risk, which can involve the airway. The combination is contraindicated.
What this interaction means in plain words
Sacubitril-valsartan and Trandolapril are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Sacubitril-valsartan belongs to Cardiovascular; Trandolapril belongs to Cardiovascular.
Why it happens
Both neprilysin and ACE degrade bradykinin; inhibiting both increases bradykinin levels.
What to do
Never coadminister; allow a 36-hour washout between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
- Amiloride + Trandolapril Major
Frequently asked questions
Can I take Sacubitril-valsartan with Trandolapril?
MediHelp rates the interaction as contraindicated. Sacubitril-valsartan and Trandolapril are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining neprilysin inhibition with an ACE inhibitor greatly increases bradykinin-mediated angioedema risk, which can involve the airway. The combination is contraindicated.
How serious is the interaction between Sacubitril-valsartan and Trandolapril?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never coadminister; allow a 36-hour washout between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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