Drug interactions
Aspirin rectal + Candesartan
Severity: Moderate
Aspirin rectal and Candesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is systemically absorbed and at analgesic doses may blunt the effect of candesartan and impair renal function. Hyperkalemia is possible, especially in at-risk patients.
What this interaction means in plain words
Aspirin rectal and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and potassium excretion, antagonizing ARB effects.
What to do
Avoid prolonged high-dose use; monitor blood pressure, creatinine and potassium, and keep patients well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Aspirin rectal with Candesartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is systemically absorbed and at analgesic doses may blunt the effect of candesartan and impair renal function. Hyperkalemia is possible, especially in at-risk patients.
How serious is the interaction between Aspirin rectal and Candesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged high-dose use; monitor blood pressure, creatinine and potassium, and keep patients well hydrated.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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