Drug interactions
Aspirin rectal + Deflazacort
Severity: Moderate
Aspirin rectal and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is still absorbed systemically and inhibits prostaglandins, so with corticosteroids it can increase the risk of gastric ulceration and gastrointestinal bleeding.
What this interaction means in plain words
Aspirin rectal and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from systemic prostaglandin inhibition and impaired mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider gastroprotection in high-risk patients. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Aspirin rectal with Deflazacort?
MediHelp rates the interaction as moderate. Aspirin rectal and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is still absorbed systemically and inhibits prostaglandins, so with corticosteroids it can increase the risk of gastric ulceration and gastrointestinal bleeding.
How serious is the interaction between Aspirin rectal and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider gastroprotection in high-risk patients. Monitor for signs of GI bleeding.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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