Drug interactions
Aspirin rectal + Eprosartan-hydrochlorothiazide
Severity: Moderate
Aspirin rectal and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed aspirin given rectally can reduce the blood pressure lowering effect of eprosartan and hydrochlorothiazide and may impair renal function in volume-depleted or elderly patients. At low antiplatelet doses the effect is minimal.
What this interaction means in plain words
Aspirin rectal and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis in the kidney reduces renal blood flow and promotes sodium retention, opposing ARB and diuretic actions.
What to do
Avoid regular high-dose aspirin where possible and maintain hydration. Monitor blood pressure and renal function if used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin rectal with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin rectal and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed aspirin given rectally can reduce the blood pressure lowering effect of eprosartan and hydrochlorothiazide and may impair renal function in volume-depleted or elderly patients. At low antiplatelet doses the effect is minimal.
How serious is the interaction between Aspirin rectal and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular high-dose aspirin where possible and maintain hydration. Monitor blood pressure and renal function if used regularly.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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