Drug interactions
Aspirin rectal + Hydralazine
Severity: Minor
Aspirin rectal and Hydralazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and at analgesic doses may modestly reduce the blood pressure lowering effect of hydralazine. The effect is usually small and mainly relevant with repeated higher doses.
What this interaction means in plain words
Aspirin rectal and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of prostaglandin synthesis can cause sodium and water retention and reduce vasodilation, opposing hydralazine.
What to do
Monitor blood pressure if repeated analgesic-dose aspirin is used with hydralazine. No change is usually needed for occasional use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin rectal and Hydralazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Aspirin rectal with Hydralazine?
MediHelp rates the interaction as minor. Aspirin rectal and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rectal aspirin is absorbed systemically and at analgesic doses may modestly reduce the blood pressure lowering effect of hydralazine. The effect is usually small and mainly relevant with repeated higher doses.
How serious is the interaction between Aspirin rectal and Hydralazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if repeated analgesic-dose aspirin is used with hydralazine. No change is usually needed for occasional use.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
