Drug interactions
Aspirin rectal + Ramipril
Severity: Moderate
Aspirin rectal and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin can reduce the blood pressure lowering effect of ramipril and, at higher doses, impair renal function in vulnerable patients. The effect is dose related and small with low-dose aspirin.
What this interaction means in plain words
Aspirin rectal and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis by aspirin reduces vasodilation and sodium excretion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure and serum creatinine and potassium if repeated or high doses are used. Avoid prolonged use in dehydrated or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin rectal and Ramipril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Aspirin rectal with Ramipril?
MediHelp rates the interaction as moderate. Aspirin rectal and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin can reduce the blood pressure lowering effect of ramipril and, at higher doses, impair renal function in vulnerable patients. The effect is dose related and small with low-dose aspirin.
How serious is the interaction between Aspirin rectal and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium if repeated or high doses are used. Avoid prolonged use in dehydrated or renally impaired patients.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
