Drug interactions
Aspirin rectal + Sacubitril-valsartan
Severity: Moderate
Aspirin rectal and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is systemically absorbed and, at analgesic doses, may reduce valsartan's effect and impair renal function. Low antiplatelet doses carry little risk.
What this interaction means in plain words
Aspirin rectal and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal perfusion and antagonizes angiotensin receptor blocker effects.
What to do
Avoid repeated analgesic doses; monitor renal function, potassium and blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Aspirin rectal with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is systemically absorbed and, at analgesic doses, may reduce valsartan's effect and impair renal function. Low antiplatelet doses carry little risk.
How serious is the interaction between Aspirin rectal and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid repeated analgesic doses; monitor renal function, potassium and blood pressure if used.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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