Drug interactions
Aspirin rectal + Spironolactone
Severity: Moderate
Aspirin rectal and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin may blunt the natriuretic effect of spironolactone by interfering with renal prostaglandins and tubular handling of canrenone. Both can also raise potassium in patients with renal impairment, though low-dose aspirin has limited effect.
What this interaction means in plain words
Aspirin rectal and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal perfusion and sodium excretion, and salicylate may reduce tubular secretion of the active metabolite.
What to do
Monitor blood pressure, fluid status, renal function and potassium, and raise the spironolactone dose if the diuretic response falls. Low-dose antiplatelet aspirin generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Aspirin rectal with Spironolactone?
MediHelp rates the interaction as moderate. Aspirin rectal and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin may blunt the natriuretic effect of spironolactone by interfering with renal prostaglandins and tubular handling of canrenone. Both can also raise potassium in patients with renal impairment, though low-dose aspirin has limited effect.
How serious is the interaction between Aspirin rectal and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, renal function and potassium, and raise the spironolactone dose if the diuretic response falls. Low-dose antiplatelet aspirin generally needs no change.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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