Drug interactions
Aspirin rectal + Tobramycin
Severity: Moderate
Aspirin rectal and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin inhibits renal prostaglandins and may slow tobramycin elimination, with effects best described in premature neonates. In other patients the effect is smaller but adds to renal risk.
What this interaction means in plain words
Aspirin rectal and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal blood flow and glomerular filtration, lowering tobramycin clearance.
What to do
Monitor tobramycin troughs and serum creatinine, particularly in neonates or renal impairment. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Aspirin rectal with Tobramycin?
MediHelp rates the interaction as moderate. Aspirin rectal and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin inhibits renal prostaglandins and may slow tobramycin elimination, with effects best described in premature neonates. In other patients the effect is smaller but adds to renal risk.
How serious is the interaction between Aspirin rectal and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin troughs and serum creatinine, particularly in neonates or renal impairment. Consider paracetamol as an alternative.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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